MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C7B3FE.615E8D00" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation

This presentation contains content that your browser may not be able to = show properly. This presentation was optimized for more recent versions of Micro= soft Internet Explorer.

If you would like to proceed anyway, click here.

 ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/master09.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
Click to edit Master title style
Click to edit Master text styles
Second level
Third level
Fourth level
Fifth level
‹date/time›
‹foot= er›
‹#= 250;
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/master09.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/preview.wmf Content-Transfer-Encoding: base64 Content-Type: image/x-wmf AQAJAAADQAMAAAYANgAAAAAABAAAAAMBCAAFAAAACwIAAAAABQAAAAwCeQChAAMAAAAeAAcAAAD8 AgAAu+DjAAAABAAAAC0BAAAIAAAA+gIFAAAAAAD///8ABAAAAC0BAQAOAAAAJAMFAP///////3gA oAB4AKAA////////CAAAAPoCAAAAAAAAAAAAAAQAAAAtAQIABwAAAPwCAAD///8AAAAEAAAALQED AAQAAAAnAf//HAAAAPsC+f8AAAAAAACQAQAAAAAAQAAAQXJpYWwAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAEAAAALQEEAAQAAAAuARgABAAAAAIBAQAFAAAACQIAAAACKgAAADIKDAAwABcAAABU b29scyBmb3IgUHJpb3JpdGl6aW5nIAAFAAQABAABAAQAAgACAAQAAgACAAUAAgACAAQAAgACAAIA AgADAAIABAAEAAIABAAAAC4BAAAcAAAA+wIQAAcAAAAAALwCAAAAAAECAiJTeXN0ZW0AAAAAAAAA AAAAGAAAAAIAAADImiAA5AQAAAQAAAAtAQUABAAAAPABBAAcAAAA+wL5/wAAAAAAAJABAAAAAABA AABBcmlhbAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAQAAAAtAQQABAAAAC4BGAAEAAAAAgEB AAUAAAAJAgAAAAIlAAAAMgoVAC0AFAAAAEZvb2QgU2FmZXR5IENvbmNlcm5zBAAEAAQABAACAAUA BAACAAQAAgADAAIABQAEAAQABAAEAAIABAAEAAQAAAAuAQAABAAAAC0BBQAEAAAA8AEEABwAAAD7 Avj/AAAAAAAAkAEAAAAAAEAAAEFyaWFsAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAABAAAAC0B BAAEAAAALgEYAAQAAAACAQEABQAAAAkCAAAAAjEAAAAyCjAAHAAcAAAAUmVwb3J0IEZyb20gQnJl YWtvdXQgR3JvdXAgNAYABAAEAAQAAwACAAIABQADAAUABgACAAUABAAEAAUAAwAFAAQAAgADAAYA AwAEAAUABAACAAQABAAAAC4BAAAEAAAALQEFAAQAAADwAQQAHAAAAPsC+P8AAAAAAACQAQAAAAAA QAAAQXJpYWwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAEAAAALQEEAAQAAAAuARgABAAAAAIB AQAFAAAACQIAAAACHgAAADIKQwAyAA8AAABKSUZTQU4gV29ya3Nob3AABAACAAUABQAFAAYAAgAI AAQAAwADAAUABAAFAAQABAAAAC4BAAAEAAAALQEFAAQAAADwAQQAHAAAAPsC+P8AAAAAAACQAQAA AAAAQAAAQXJpYWwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAEAAAALQEEAAQAAAAuARgABAAA AAIBAQAFAAAACQIAAAACEAAAADIKTQA4AAYAAABKdW5lIDQEAAQABAAFAAIABAAEAAAALgEAAAQA AAAtAQUABAAAAPABBAAcAAAA+wL4/wAAAAAAAJABAAAAAABAAABBcmlhbAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAQAAAAtAQQABAAAAC4BGAAEAAAAAgEBAAUAAAAJAgAAAAIJAAAAMgpNAE8A AQAAAC0fAwAEAAAALgEAAAQAAAAtAQUABAAAAPABBAAcAAAA+wL4/wAAAAAAAJABAAAAAABAAABB cmlhbAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAQAAAAtAQQABAAAAC4BGAAEAAAAAgEBAAUA AAAJAgAAAAISAAAAMgpNAFIABwAAADYsIDIwMDcgBAADAAIABAAFAAQABAAEAAAALgEAAAQAAAAt AQUABAAAAPABBAAcAAAA+wL4/wAAAAAAAJABAAAAAABAAABBcmlhbAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAQAAAAtAQQABAAAAC4BGAAEAAAAAgEBAAUAAAAJAgAAAAI2AAAAMgpgABgAHwAA AEJlcm5hZGVuZSBNYWdudXNvbiwgRmFjaWxpdGF0b3IABQAEAAMABAAFAAQABQAEAAQAAgAHAAQA BQAFAAQABAAFAAQAAgACAAUABAAEAAIAAgACAAIABQACAAQAAwAEAAAALgEAAAQAAAAtAQUABAAA APABBAADAAAAAAA= ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0001.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Tools f= or Prioritizing
Food Safety Concer= ns
 =
•
•Report From Breakout Group 4
•
•JIFSAN Workshop
•June 4-6, 2007
•
•Bernadene Magnuson, Facilitator
•
•
•
•
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0018.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Selection of compounds/agents
for inclusion
•
<= span style=3D'font-size:88%'>1.Known single agents
<= span style=3D'font-size:88%'>2.Known complex mixtures
<= span style=3D'font-size:88%'>3.Unknown agents –  <= /span>
•-may be a= dded based on observed adverse effect
•-structur= al alert
•-emerging contaminant arises
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0017.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Conceptual Illustration
Relative risk
Chemical or Microbial agent
Relative risk =3D = Exposure (ie. Concentration in foods x consumpt= ion of food
Hazard assessment = (e.g. BMDL, etc)
Note – ADI, = TTC not relevant for micro-chem comparison
Safe
O
O
O
O
O
O
O
A
B
C
Length of line represents degree of uncertainty around point estimate
TTC
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0017_image001.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhzAHgAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAADL Ad8AggAAAAAAAMz/zP8AAP/FxQECAwECAwECAwP/GLrc/jDKSau9OOvNu/9gKI6kCJxoqq5rwL5w LM90bd94ru987//AoHBIvLmCx6JyyWw6n9CodEo9JX/XqnbL7Xq/4PAs2yOLz+i0es3umnfvtnxO r9vl8Vz+zu/7/4A8e0aBhYaHiIGDNouJjo+QkUuNNJSSl5iZSpZUnDGemqGio2NsoC+npKqroalP riqwrLO0h7JMt1a1u7yjuZtCv73DxGLCRL/HxcvMU8rB0M3S03im0dTY2WDPSNd+3NrhYeBY3n3k 4ulb6GXmfOzq8VHwcO539PL5k9bdgPj6AO2NE1jnX8CD7dYkU4SwYRuDhPr9geiwYimFBOlQtMiR /8XGShnnfOxIEsBIGQv9lVxZ5eSnkNVYyoTiEkbKiTNzNqmJCuZDnUCL8PTok1/Qo+UwSvyGtGlC NTeZOp2KY2iLokqpar0IFWvXrWBtGk2KM6zZWGN9WNVztq2urGSlujW7NkXUc2fqzi12913evXv7 3vsL2K1gO1b1FuZ1uCDhxXS9pkkM+WxjjY8rb70sMrNmqpxjDvy8WTIayqS1hhanODWp1eFauxYF W5vs2ZpqZ7vdkbfouAF9WxSe9ulB4g6RfwWi/CfuegB1Y2t+PLjpadStR78uLfv278yTP4euTzo1 7+W1h2+IPl/7L+axj9fx3kv87vPZggeeQoD///8ABijggAJKUp86B3LRGIEMNjiggflVpR5/KDho oYMQRsjIhGrBcOGHD0aSIGscGqcCiCj+l6GGIO3X4QspprgiiyiVKIiHMYI4I41iuWhifzl+uCOP RPl4I4xBXjgkkWgZSd4KSSopIpMvOUkfjlE2uCSVb6W31IlZajkll0V6uR4LYYoJyYix2fgkmGmG uCaZZbpHUJwEbsklmy1d4wCeDyYBAQqCPkAooYZ2OaiiiZqEqAOHWtFooZAyWqmjkl5KaQORmjTp o5xaGiqmnmoKKgOdLkqqqpuiKqqrq36a6aitLpCqrKXS+qhddwIaoJ5U8tlJr76qOCadvFqpH5r/ xRo7J7LJmknhCc06+4iw07l5JZLVAssktlLc1wy48ikrIXvQRmvnl+YSSS5N3I2bbqfrnlndvKTW O60878rb7obo4tuvE+IyM/AyB+MSr8H45svvwgg3nPA+7EoL7cTAVKzvxdouey9LqFn8o8i9eRZP wRHLFPLGI7NcsjEdn0sxbTOt/LDGOB+7ks0nQ1yjLzWbjKDPVdKsstDpoPyz0SAjTWLO++pcEs9D Q/0i0zs73abVLXsb8Ggkv4nMa0HD/G8N5EyM8Tpa20Z0j1hP3fZub/cE9NFmh73tzK2UDbbLYg+h tt/bxBwR37lJbDjAiGeyNmOLo70T2QJH3mLj/5g8vovmdadN+byccy25wg1/DvjeGZced8+iB666 19m2jvrrmVvOVeq01w6HrbQoXXTul4CiwADElzCqc/YKBbzjRgxP/PPQRy/99NQXj5nsHi//7BgB VO/999/75jvci4V+JErdg6/++tZ3hr3M5d9cifPs1y+9+HXXWZj5rn+SfvHG491vroa7/cmvKsML 3fjsBhn+zU4PCszfVSrjwOyxLnljo+ABN9g1DAaGg1XzoASzdsHTWVBwmqkg/EDYPxEahoVPc6EM LQPDrc2QgAYsYQ1XmMEG7pBu7ztc/HRIxPMVEDAqFOIPGXfEDxYxaSNUVw5DaEIeolCDT4xh1P+2 GJks2pCLHaShF90WRCZOEYpnu1wT55JEM45RiT0cIhWXODrMsZGO5bphGLs4xze68Yo+9ON5okgv 7V3LdktboyEN0cYTthCMi8RLGm+nvEgecpKJrKQlE9FIKz5yk6D85B9DSUpR1rGUqDSlGlPJylE+ sJWwJB8OY0nLCeqxlqxcIC5zp8td+oEAwAymMIdJzGIa85jITKYyl8nMZjqTmZ1M5TOnSc1qWvOa 2ERmNFGZzW5685vgrOY2SxnOcprznOAcJynRyc52ulOZ6gzlO+dJT3fGE5T1zKc+v3nPTe7znwCd Zj8tGdCCGvSYA43kQRfK0IQukqEQLahDDRn/0Yruc6Las6hG6YnR5W30o+3sKPBASlJzijR3JU0p P31ZC5W6FJsnpd1LZ0rNmL6Opjhtpk1Vl9OeJnOnpfOpUIsJ1IYN9ajBLCq+kIpUpc6LqUd1arqg OlSpQouqQg2gVrfK1a569atg3SpWfcrSlo41p2WlxVnRmlZWrBWnbXXrW2ca11XMla51JcVdX5pX ve5VpX0dxV8BG9hQDDalhTXsYUmaWE0slrGNxcRjQRpZyU52o5W9xGUxm9lIbFajnfXsZysaWkiM lrSldcRpI5pa1a6Woa1NxGthG9tDzHahtbXtbQ2aW0Pslre9DcRvCxpc4Q4XoMUFxHGRm9xfBS53 nwkAADs= ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0017_image002.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhqAECAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAACn AQEAgAAAAAAAAAI6jG+goYDY2HppRSrdpXG/PnFW+I0OBp6iRkImlsXoO7NqacOpTq+y73Hlaj9c UXg87IhBZc/YrAwDBQA7 ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0017_image003.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhJgAXAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAAAj ABYAgAAAAMz/zAIajI+py+0Po5y02ouz3rz7D4biSJbmiaZqWAAAOw== ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0002.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Risk assessment
Risk management
Risk characterization
Screeni= ng
Hazard    X    Exposure
assessment    assessment
Intermediate level
risk assessment
Full level
risk assessment
Overall approach – multilevels
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0002_image004.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlh9QFHAXcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAADz AUUBggAAAAAAAAD//8z/zP//mf///wECAwECAwP/GLrc/jDKSau9OOvNu/9gKI5kWQJoqq5s2wZE LM90bd94ru987//AoHBILBqPyKRyyVQGXNCoC9asWq/YrHbL7Xq/2ad0LKWCz+i0es1uu9Vispxl ftvv+Lx+zzfG54AAdX2EhYaHiIlHf4Fyg4qQkZKTlHCNgY+VmpucnZ44jJdln6SlpqeGoaJQmaiu r7CxTaqrL7K3uLm6O7S1K627wcLDnb2+KcDEysvMfcbHgs3S09R2z8fJ1drb3EnXvtnd4uPkoNBR 4eXq69zftens8fLK7qvw8/j5svWi9/r/AD/xu+QvoMGDkQY2KoiwoUM+CjE9nEhRUURADCtq3Njl /+KcjBxDimTi0dHIkyg7nmOVsqXLWSunvJxJk0hJMiBr6kx5c0zOnUBD9hwVtGjRoeiMKt2JlOXS py+byoRKFaVUW1WzCo2JVatXilfpfB37MOwvsmgPmlXxM63bZmuRvZ07Ly6KtnTz6rIbTa9fcXzx /h2MKjDhw9MMI15Mj6tYxpCDKY5M+dbkyphdXc7MmdTmzqA3fQ5NWtLo0qgRnU7N2pnjs61jp3rN VrZt17Tv3t6dZzXv32B8Ax++RTjx41aMI1/uJLdu5tCxKI9OPcj0ISaya9/Ovbv37+DDix8fXvqA 8+jTq1/Pvr379/Djy59Pv779+/jz69/Pv7////8ABnifAgQEIMCBCCao4IIMLkjgFQEIKOGEFFZo 4YUYZqjhhhy292CBDYYoIoMfVhFhhyimqOKKLLbo4ovzlQjiiDSKKCNJMOao44489uhjizfOWOOQ CgbpxI9IJqnkkkwmaaSQREb5JBInNmnllVhmqSV+U0IZ5ZBd+rHlmGSWaeaPYXr5JY1p2nTmm3DG KaeEbaq5po2CgTLnnnz26Sd6dcZg4J1g5nlDlX8mquiiSwYqw6CEsmmoDYgyaumlmKLo6AyQRoqn eZmGKuqo/y3gh6eSgkrqqqy2yt6mh6I6Iqw+VOrqrbhaSmussoa4Kw+25irssHH+ymuvJE5aQ7D/ xDbr7JXGgoJsg9HmwOyz2Ga7Y7XSTuugsjRcq+24oxZg7rnopqvuuuy26+678MZ7Lqfefqsqufiu Ku++/Pbrr7z01psgt4fmazCp/yas8MLwBizwgQRTevDEmTJs8cULO/xwxMtS7DGjGIcscrwaC8xx uB+n/OfILLeMbsn1nsypyjTv6fLNI8PsrcyP1uwznDgHfbHO0/Is6M9Ilyn00goTjazRBSYttZZM V92v071CLe7UXPNo9dckP/owglp3bbaSYKfdLtayln322z2qLXe6bKPqNtx4wzj33gXU7endeQe+ It9z+x0p4IInziHhchtOKOKKR34h42o7fifk/5JnLiHlaVu+Juaah+4f52B7/iXooqeeH+lfmy4l uDOrLjt/rFvtOpGoz647fLVXfXuh9+4ufHy9M/17jbkPr/x5xS99fKoQLi99e80L/fyssPc8/fbo VR/09Z9Gzz333uMMvq/ZHz3+9uXffD616Ue9/vTtu/x+ssHPL3z9Ld9vr/j6G14A+Mcy/xUpflsL oOQIRMCciW1sAkieAhP3oQaKzIADQ+AEUycjC4YMg2TT4AYzFyQPYgyEEBPhCCkIDBMO7YFjk+AK k9YlF1oMhRFU4QzPliYbMgyHMtzhx0xFjk6ZTIdC/BnUTmHEmCExiSpbYmEgmMP8QZFiUtQMFf+D eMVnZfEVTdzZE7tIri/CIoxFGyMZsWXGWKDxaWpcI7HauI8txlGOuKKjZexoRTzeSo+4eGPW7ujH UQEyF4JsGyELialD7oWPAGQkqRy5i0TabZGS/BMlJQPJ5GQyVJsUhiX/hslPFit+gOmkiUy5qFDS Q5WzYKUmUVmOUR6ulLLMkivhAksc5fKUQLHl43D5SyXt8gu09EYvl5DAYhozmXqA5iKWeSRnaumY Z5DmNCHIRWvCiIiSOYQwL0dMb7IIm2vQ5qm4WU5zakqdzlANNb3hTh+hsw3wLMI4P9fOel7onm7I p03mSSV/flOghUAodgi6CIMCSaEJTcQ+T9f/T4f6B6B4gKh1GComi3IIoxm1CEf16VENgbQ3ImVn H1XnQ9/tI6UxrGjeWmo8N0Jioq9baepo6jybwnRjMsUbT63nU4mO1E3KG+r3zpiQo2JneUo1H1Nv 6lQhNDNzUXXfVH96RJ2KLqv2A6NpqmodqIK1gGJtqkojubuzolUzY12rJ5Pq1gvCNa4x9Wro6mrX wkwCp7gLKtz4+sG7qjWvbNUdYU/o17+SFQhXldxiX8hESgAWeImd3WRvyESNrhOxcx3eZn9YWcs+ 9geRjdxoM1Zax8p1lXRd7b86W4nLIk+wb5NtwlrrWtDCVrS69Rdv8QpUvWouuMIthWepdNpa/5kV ufsyxXK36dtYxha6YfOMaJrbg9QqDrvR1e52X2td4IK3YeLVhG2hF9r9nRe9AuHEerFnXKy+913p VS93gfXc+7Irv7XdLy/66191Adi05PWleQtsYE9MV5kJZiaBGTwvBztYwDrwbuIovK74FgPD1pow hy184QhXc8EcNheJP2xiel43xX0rhkBArKcXp1jGM25xQW08Yvl6hsYFG99J8/FgJwBZYtsbMpGV e+SOSU/J+iiykXXcUOVB+R9ShnB1Fay7K2NZuk1GWZezPBEyM5fKHVWdlw1iZuoWN7ORWzObmRjm 2GlOzmqhM5pJSsI2awTPqK2z9hQHaIT42f/NXYUzDw/NEUbrU9Dqy1uhHTLp7kJafnCrNKW1uGek Lto2jn50p59qNjyHWr1gvLSG81XoU9c21aO26tQq7WrLwnrLElaipgv05zOq2me7flSvb/3m9nos 2JwaNqdxfWIs1hpYFXn2QmNdVmdLN9pu/PXBkA0KbPua2pA1GLetBZY6ghu1+Bp3hsud7XM7V1vq 5gW7v81sF3tR2n4o8x7d3d17V1Lf5q73jocVb8gCvN0Cr3KuCm6dsgRS23/E9ywcvu+Ep5lVDLcJ xQNe7N9OUuIQ2vTD+c3fj1cD5PEcucX5DEqUh0HkFe94eS+VcWY2xOVWhTijak6Smz+S5AP/3jnO O+JzROrcTzxPjqErefQ5gVMdQ79D1CHbdDglXQtTD2jWa1V1M129OHlmOtAzLKevc2HrbEC7pcce 4jeZnegBefuyuo4lucMdIGpf+8o9vSW7eyHvaAA8L+jeKMGnPe6GtxbhkeT3bMZ9GPMNn7ELv5HE 313seyc1kxoPB7wTI/Loq6+LOJ9Oz0OemvzjD+kP/+XTmzj1+Vk9PlvvembD3j6yDyjtRYn6+uHe 8hGN8itf7/sYAT8Vwh++7YsPn9yjdMnKl7kMbu+h40s0+Z/vffvc43yIQD/6ia4B9QFl/YR8P/vE 3356uh/8ujAD9PC7Aeyf/pTy9/z92i8f//uv7378p798ZGF/Nud/y9c+Adh/BCh9McA/BygPAtgt BQiAY/GAVCIN8Ic/NsCAE+iAiZF/3tOA7ECBx6KABKCBXyGC+tSB//eBGxiC1HCB/yN+9QOCUPeC i7cegbJ/FhGCKEgpN0h+2KGDyLcOPeiDbFdjzYcX9LcURWhwNniEQcZ9yrKEQdGEtWKFQBRHWoOF z1dL2gCDB2RFX0SFM8GF8nZyRwdIZMgTUGeGggJxm7SGI+GG3faFv4ZNclh5NWiH7EQefviHgBiI gjiIhFiIg0hFEeQcgoCIgwSGjPiIkOiIkDiJRUKJlniJj6OIkghUm4iJnvg5nxiKfyOKpP9IioFR iq/Tiai4ihHEiq5IIq8Yi4h4irKIPapYi5Z4i7gIirvYi22jib6IJ8E4jA5CjKZojMiIPMCYjAek i8xoN894ic4YjY9Ii9QYQtN4jWCijZHIjdRojd64AN4Yig0wjtxkjswIjuYojug4ieXYjjsDj8io ju2oACkkjzGVjc+oj/hoN8vYjznEjgAJR/yYjAU5kJ/zjwD5jgjZNg05ig+Ji/Qojw4QkRBpkaeD kbI4kRrZkR4Zjx+5ihwZkiRZkttokqaokCi5kiw5MK3Ykp44kjA5kx3JADSZiyp5kzqJkQy5k1uU kz4ZlAspkEIZQ0BZlEi5jgc5kzKZlE7iGY1LyZRH+ZRUWZUo2ZRWmZVa+ZBYuZVe+ZXo2JVgOZZk mY5TWZZomZbDKJZq2ZZuWYps+ZZyOZfueJZ0eZd4OYt2mZd82ZdZs5d+GZiCiTuAOZiGeZhFUpiI uZiDGZeM+Zh56ZiQOZlyKZmUeZlpaZmYuZlgqZmc+ZlZ6ZmgOZpOKZqkeZpBaZqouZo0qZqs+Zor 6ZqwOZshKZu0eZs8qZi4uZslaZu8+Zv46JvAOZzrqJvEeZwDKZzIuZxm6RxRyZzQKYrKGZ3UuYvT WZ3Y+YqBYYjc2Z3e+Z3gGZ7iOQIJAAA7 ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0006.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Risk characterization – Screening stage
•Hazard assessment = ;
–Benchmark dose (BMD), = ADI, RfD, TTC, MOE
•Need common scaler = 3;
–Structure/activity relationship
•Exposure assessment= 3;
–Concentration in foods
•Output - Yes – No decision
–Not signif public heal= th risk, or need more data or consideration
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0005.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Risk assessment =3D
Hazard    X    Exposure
assessment    assessment
Screeni= ng
Risk characterization
Management
 de= cision
Mitiga= tion
=  Continue evaluation
Do not= hing
Risk management
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0005_image005.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlh2gEnAXcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAADY ASYBggAAAAAAAMz/zP//mf///wECAwECAwECAwP/GLrc/jDKSau9OOvNu/9gKI5kWQJoigZD675w LM90bd94ru987//AoHBILBqPSGNApWIln9CodEqtWq/Y7HTJXGm/4LB4TC6bydyu88xuu9/wuHyY Zq7n+Lx+z+8T601+goOEhYZngCl3h4yNjo+QNolekZWWl5h5kwCLmZ6foKFQm52ipqeoqTGkqq2u r56ssLO0tYKytrm6u2a4vL/AwVG+wsXGxzvEyMvMzMrN0NG8z9LV1q7U19rbn9nc3+CO3uHk5X3j 5unqb+jr7u9h7fDz9FtdlPX5+lXy+/7/ye5xAkiwIJB+BhMWRKiw4T6GDiPOgyixojqKFjOGw6ix /6M2jh5DRgMpsiQykiZTBkOpsqUuli5jzoIps6YqmjZzisKps2cmnj6DRgIqtCgjokaTDkKqtOke pk6jyoEqtWobqlazohFYSqvXQ1i/ir0SdqxZKWXPqkWSdq1bOlzfyp3Tdq5dHXXv6q2Rd69fGH3/ Cg4s2C/hwnoPI7areLHcxo7dQo6sdjJls5Yvi82s2Svnzlk/g64qenTU0qabok6ddDXroq5fB40t uyft2jlv466pe3fM3r5bAg+ecjjxksaPh0yuvCPz5hkDC5hOvbr169iza9/Ovbv37+DDix9Pvrz5 8+jTq1/Pvr35rlTcy59Pv779+/jz69/P3zv8Kf/9BSjggAQWaOCBCJ73nxQJNujggxBGKKGEC0Yx 4YUYZqjhhhxiVyEUHYYo4ogkltjeh0+YqOKKLLY4IopJuCjjjDTWGCCMSNio44489igejkf4KOSQ ROoIpBFFJqnkkiEeWQSTUEYpJYJOEjHllVhmWV+VQ2jp5Zdg/ghGmGSWaaYAXApx5ppsTplmEG3G KSeRbwIx55141ljnD3n26aeJe/rw56CEahhoD4UmqqiDh/Kw6KOQCtjoDpFWaql9k+pw6aacqpdp Dp2GKmp4n+Iw6qmoejhmqqyiWuoNrcYq6qs2yGrrprTWcOuukeZKA6/AKurrDMEWO+iwMhirbJ7/ yMaw7LNyNgsDtNSuKe0L1WZL5rUuaOutl9y28O24V4Y7ALnoQmluuuwmuW678Pr4brz02jhvvfi6 eG++/AK6ar8Ak7hvwAQb+m/BCGM4cMIMM3pwwxAnuHDEFEv6cMUY9zdxxhxjenHHINO3ccgke/px ySijN3LKLJN6csswf7dyzDSr+kXNOMv8cs48o7lzzzjPDHTMQg/dctFGp4x00iUvzXTITj/dcdRS Z0x11RVfjXXEWm/dcNdeJwx22AWPTXbAZp/db9pq58t22/W+DXe8cs/dbt12p4t33uTuzfe3fv+t beCCV0t44dAejviyii9ubOOOBwt55LxOTvmt/5ZfLmvmmrfKeeepfg76qaKPPuvPpsNbeuqcrs76 pa6/XmnsskNKe+2L3o57orrvTmjvvv8JfPB9Dk88nsYfP2fyysfJfPNsPg/9mdJPX2b11oeJffZf bs+9lt5/j2X44ruJevm7ko++uuevv3n77nsOf/yhz08/6fbff/rN+herfv9C+h8AeyTAAe6ogAa0 V/4SOLsFMtB2Dnxg7iIoQd5RsIK/uyAGhafBDRavgx5EHghDuLwRktB5Jjxh9FKoQuqxsIXXeyEM tSfDGXavhjYEHw5zOL4d8tB8/PshBIMoxAkSsYgWPCISM6jEJXKwiU78IBSjKMIpUrGEVrwiCv+z qMUVcrGLLvwiGGMoxjHSsIxmvCEa06jDNbKxh258IxC1IMdo+bCOM0IgHjV2xz22SI9+1A8gA4mf rhDgkIhMpCIXychGOvKRjiSkAmUAyUpa8pKXlKSeZoDJTnqyk5qkkSE/ScpSLjKUeeSkKVdZSlTK aJSsjCUmXakvVcrylpCk5R9tictenlKXK4KlL4d5SGAGk5fE9KUxVSTMZPZymf6ipDOHCc0SNXOa sqymwJCJzVhq80Xc7OYqvymia4rTlORsUjjPScp0dsic7PykOzkEz3iCcp4Gk6Y90YnPDNVzn5bs pz/XCdCACvRCgzxodxKq0O0wtKHZeShEryNS0YlWp6IWnQ5GM7pRi5rgAhm1kUBGStKS3iOkNTKp SlfaBZTSiKUwXalLZxTTmpJ0pjKyqU5bitMW7fSnKOipT4G6U6GyiKhFNaqKkKpTpaooAQA7 ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0005_image006.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlh0QE+AXcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAADP ATwBggAAAAAAAAD//7vg4/8AAAECAwECAwECAwP/CLrc/jDKSasLNuvNu/9gKI5kaZ5oqq5s675w LM90bY/Yre987//AoHBILBqPyCQop2w6n9CodNpjUq/YrHYbsnK/4LA46h2bz+j0rKxuu8/styUu r9vvbTp+zy/q+wp/gIOEhUCChomKKYh7jYuQkZIfj5OWlxCVdZqYnZ6LnJ+io46kpqShagGpp62u X6uvspKscLWzuLlIsbq9gLdivL7DxE/Cxch5hsfJzWbAYMzO09HL1NfYa9nb3CrQ3eA231rj4ebU 5efqLOlU7evwuu/x9CLzUPf1+qP5+/5zffr9GxhBYBKDBBMWQqhQIUM/DSMSeyjxnzQ3FytqREVx /6O+jj8yehx5SSTJkxVAVlGJsiUZli7DwbxhMqbNBTPF5bzJU8jOnug2AR3K5yfRZkZjJD3KFMbS psNqwoJKFc3Tqr2uesMKVCsjrl1Vge3p9UTZsWgBprV5lkTbtXAvxI35tsvcu7vq4k0rda/fNXr/ cu0r2OIYwoUTMwqsGBLjDIgbS7b3eLK1MJUtk9VcMfMEz5zphh5tAjTpk6ZPj0yt2g5rnK1jc3gt G+MW2rUT4s6d5vVu3nDIAR/I+vfwesaPx4usPJtp5s0nQ48edMp06omvY0dqPfn2btq/I/PsXXwW 8uZll09/JfN69tPew5cSXtz80/LvkzGmf3T+/v/8NfEfgPIQqI5eAxp4kIAKStegOXUl+GAr9U34 ylsVWjhUhhqewuEKH3bIloQiDlFWiCWKciKJKQbhFYotenJijHexSKMPL94Yl4068qAVjz0mAmSQ NJlIJFpDHvmLktWFxORgT8Z3SJRVJUmlDEZZeaUcWm75wk8weolcl2JaRWaZz5yJZjBqronCTGG6 eU6cchICE511gtNmniXcyacvfv6ZVZGCorRnodYhOigNhyqKj6MFagPpRo1O6gFFlVq6i6a4PJQp pxp4CuosDH06qlpfmnpqSKquKgGeOLXq6g6wzqpMC7Xa6kquulqFq6y91gBssA30MyyxsLGDLD3/ xy4LQD7NOqustCqCSO2B16r4TrTZmtVttd5+K+Ob4n6SDrfUnlsuN+imW1q7614Kr7Pj8BqvkPPS 61a+90LGb78p/bssMPYCbKfBJT1rD8IlrVKLwAM7nArEEbNCccSUMDzupRonc3HHyYIclciLftyx wyRnhXLKuUhsMsMSs9zpyzLXbPPNOOes88489+zzz0AHLfTQRBdt9NFIJ6300kw37fTTUEct9dRU V2311VhnrfXWXHft9ddgh72Py2SXbfbZaKet9tpst+3223DHLffcdNdt991456333nybLcDfgAcu +OCEF2744YgnrvjijDfu+OOQRy755JRXbvnl/5hnrjnmAWzu+eeghy766KSXbvrpqI/eeeqst+76 67DHLvvssK9O++2456777rz3Xrntvgcv/PDEF2+85cAfr/zyzDfvfO3PRy/99NRXz3jy1mev/fbc 84599+CHL/74nn9P/vnop6++4Oav7/778FPffvz012+/7/Pfr//+/Keef//nWwUAB+g/AsYvAAT4 nwEXSDkFMlB7CCRAAh9Iwcw5sILTi6AEL4jBDhKOgx5sngY3GMISXs+E3BuhBCeIwhZ+0IXZU+EK QQhDA9Kwhr2T4QpZiEMU3rCHudPhBgUIRBP+sIi0k9gOeYjEEh6xiUlcIhOhiMEnUjF2MrTiFf/d p8Utti6LXqxiGI8HxjE+sItmNF0Z02hDNg5vjW4EIBrjGDo40nF/c7xj+aSYRz1Wr4/GI2L/7OjH +gGSeAEYwAAEqT9CFvKA6kukIhV5yOc58pHwq2TwJDnJRd5vFXzEZCPTx8lOajKHZ5MiCUVpv1Pu rpSmJKUqZ7lKVtLPlbqDJSUjSUtV4tKWxfvl7XTpSV72conCBKbwkik7YjIziMfc4TOVmUPyOZOL 0ZwhNW85vmtiM5vT3OYrUwg4b37zmOEUZy5T2DliFvOcs2SkOrmYwkWak4tpm6chu+fOdOrzn3/z Z+nuCdCCqpGfnZykQA2qzoWqLqHvZKhEReei0IcmVJ4TzSjnwIc2jXp0ox8NaQcrKtKSBtOkKG1j SlfKP5Ky9KVJhKlMITnTmkbSpjgNYE53Gj6X8vSnm/MpUIeKPKIaNXpCPapSG5fUpToVcU19qlQH F9WpWlUAVb2qVLOqVadytatK/SpYjSrWsQ61rGb9KVrTutO1shWnbn1rTeMqV5nSta4vvSteV9q3 vvr1r4ANrGAHS9jCGvaweEsAADs= ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0005_image007.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhXAAtAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAABZ ACoAgQAAAAAAALvg4wECAwKdjA2py+0Po5zyIIqz3tQGDoZi5Y3mCXofyraQ6sYyAM/2Wd96Wu6+ lvsJI8GhkVE8KpNKI7M57DVWUF3vUI1Ks74n14X9isfksvmMTqvXbGe4LTII5lT4Rj7P1+2LPQ2f p8fnUAcYeOhnFyDwYXiIONjHuPhY+RZJWfl4EamQqamXiAlKx9mJBGp6ivQZujoBqPpKtCg6+yJ7 W2FUAAA7 ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0010.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Considerations for screenin= g step
•Level of certainty ? – quality of data points/number of observations
•How low below establis= hed ADI, RfD, TTC, tolerance levels? Margin of Safety
•Helpful to have widesp= read acceptance of approach and levels
•Need unbiased evaluators involved
•Post-analysis and re-visitation needed=
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0012.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Inputs for remaining risks
•Amount in food
–Analytical methods validated?
–Food consumption ̵= 1; diet, special populations
•Animal tox data; =
•Human data preferred – epi, use to develop upper bounds if no effect, d= ose-response if effect
–Exposure biomarkers= 3;
•Assessment of health outcomes
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0009.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" PowerPoint Presentation
Risk assessment =3D
Hazard    X    Exposure
assessment    assessment
Screeni= ng
Management
 de= cision
Mitiga= tion
 Continue evaluation
Do not= hing
Interm= ediate
Increasing information,
 redu= cing uncertainty
Additional research to reduce uncertainty
------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0009_image008.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlh9QFvAXcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAADz AW0BggAAAAAAAAD//7vg48z/zP//mf///wECAwP/GLrc/jDKSau9OOvNu/9gKI5kWQJoqq5s2wZF LM90bd94ru987//AoHBILBqPyKRyyVQGXNCoC9asWq/YrHbL7Xq/2ad0LKWCz+i0es1uu9Vispxl ftvv+Lx+zzfG54AAdX2EhYaHiIlHf4Fyg4qQkZKTlHCNgY+VmpucnZ44jJdln6SlpqeGoaJQmaiu r7CxTaqrL7K3uLm6O7S1K627wcLDnb2+KcDEysvMfcbHgs3S09R2z8fJ1drb3EnXvtnd4uPkoNBR 4eXq69zftens8fLK7qvw8/j5svWi9/r/AD/xu+QvoMGDkQY2KoiwoUM+CjE9nEhRUURADCtq3Njl /+KcjBxDimTi0dHIkyg7nmOVsqXLWSunvJxJk0hJMiBr6kx5c0zOnUBD9hwVtGjRoeiMKt2JlOXS py+byoRKFaVUW1WzCo2JVatXilfpfB37MOwvsmgPmlXxM63bZmuRvZ07Ly6KtnTz6rIbTa9fcXzx /h2MKjDhw9MMI15Mj6tYxpCDKY5M+dbkyphdXc7MmdTmzqA3fQ5NWtLo0qgRnU7N2pnjs61jp3rN VrZt17Tv3t6dZzXv32B8Ax++RTjx41aMI1/uJLdu5tCxKI9OPcj06th5XM/O/cb27uBlfA8Pfjx5 7ubPY0+vnjr79tDfw18uf/7x+vaH48//ez//3f/+/WdbgALGRmCBrB2IIGoKLkhagw6CBmGEnE1I IWYWXkhZhhpCxqENBIQo4ogklmjiiSimqOKKLLbo4oswxijjjDTWaOONOOao444zDrCSYELwKOSQ RBZp5JFIJqnkkkymOMCTP6LR5JRUVmnllVhmqSWMT3YZ5RlbhinmmGSWaWaWXabp4zlABnHmm3DG Keeccaqp5pdg0Knnnnz26WeNdtqJ5xd/FmrooYi+GWigg3qR6KOQRirpkIsu2mgXk2aq6aacjlhp pZdy0emopJa656efhrqFqay26iqWqKKqqhav1mrrrTzGGuusWeDq66/AqqirrrxiEeyxyOI67LD/ xV6R7LPQjrrsss1aEe212CY67bTVVpHtt+DSue223TYR7rnoijnuuOUyke678Da57rrtLhHvvfgK Oe+89SqR778Ay7jvvv0mEfDBCJ848MAFI5HwwwgvvHDDR0BsMb4SS0yxERd3jG7GGW9chMckXwvy ySITUfLKx57scspDsCzzrS7XDHOQM+dsas083+ymzkBvyvPQPgMR9NGRDq100T8g7bShSkfNtA9P V31q1FKzKaXVXCuKNdZT99D12GN+bXbYPJCtNqxmn601mGvHzWTbdKO9g9x4H0n33nbrkPffue7N 99t5Am44oIIL3ncOhzfOZeKJL46D45QLCznk/5LfUPnmJF7ueeYgcr6556SDXoPolJOuuuk0oH64 6rCzPoPrf8Nuu+wy0B637byvCU2bRus+du+94x6D8FwTT7zxBSD/tPLKM+/80dBDL/30OVdf/fXY r6y99tx33/H334cv/sPkk2/++QGnn/767GPs/vuEExr/v/PPD//95+af//78y5b//AfAAEJrgAMs oAFbhsAE1s9RCzRZAxGowAjaaoITrKAFW4VBDGpwg6TqYAc/CEKhiXCED8RUCV91whOScIXaamEL XwjDQsnwhjSsIZ9uyMMc6nBOPAyiD3/otSD2MIWiIiKijMjEISoxTEyMohOfyLYoNhGJq6Kinv+s yMUpanFuXOwiFmn1xSKG0YpeLGORzsjGNKoxcGw8oxvfiKM42nGOdKSRHfeIxzw+bo93HGOv/AhG QPJRkMYiZJIMycg+KtJEjIykIx8pokhacpKPtKQmMelHTXqSk2r0pCh9h42tUbJHoxQlKJ+YylSu 8oetbOUrYRjLWM4ShLWs5S0jmMtc7jKAvezlL+MXzGAOU3zFLOYxp5fMZC5TeM1s5jNdF81oTpNz 1azmNVOXTW0i0llv7GY3twk4cYqTnHgzpznRuTZ1qpOdw3PnO79pLR3KU57wdNo995nPoO3zn/3M 3j8BSk9vLXCgCA1oyRDKUIWOj6ENLai52Af/0Yo6NGEVzehF25dRjUrUXc7rqEg3ei+RmpSk7zKp SlHaP5Wu9KP2wqZLXcpSbM30pjU94E1xClN/vW6nO81psIBKVKH6iqhINeoFkZrUnhqsnUxlqlJZ FdWqTlVaVc3qVU2YVa061WH67KpYt5o0sZqVrDE061m/WjGBqlWtaP3TW+dKSnCYkmR0pWtct5hX vbKVYw/tq19/d1eMCravez3TYQ+bWDItdrGNheJjIfvXkeFvso+N7JUwi1nNUomznPVsIUE7WdEu krSgNa2RUIta1VKKta2trMpsClvWuraOta3tbRGXW93KNmYM7G1ud/tH4Q73tzhTlnGNS9wV/y33 uc1F0XOnG90STfe61a3kdbGL3J+FcLvbjS54x0vc8Zr3tuZNr6oMwN72uve98I2vfOdL3/mqK73q xWJ998vf/vZ3S/gN8Hr9S+AC+xdNARawfg3M4AbDd7MJTvCAHUxhBlcpwhiecIU3/F95YTjDC+aw iOs72g9LOMQjTvGDT2viD2tYxTA2AJJaTOMXxzjFa6Sxjm18YxG/Vsc7RnGPRwxHIAeZsDYYMox1 ZOQm1/UdN1CyinHrZCPzWMoOtlGVq3xlLFsYlVt2cpe9XGCBhXnLYybzgV905jOnWc38dVGb2/xm OJPYuXOms5DtXGYn5XnOdeazfKX75zy/sv/QhQYlohGNyUUv2pGOdjQeIx1pN1Ka0l689KWdqGlN /8gEoA61qEdN6lKb+tSoTrWqV20C5whCALCOtaxnTeta2/rWuM61rnfN6177+tfADrawh03sYhv7 2MhOtrKXnezAMPvZ0I62tKdN7Wpb+9rYzja1na3tbnv72+AOt7jHTe5wc7vc6E63utfN7na729jn fre8503vetv73seON773ze9++/vf5nZ1AABO8IIb/OAI77W+E87whjv84e1eOMQnTvGKW/zZEr+4 xjfO8Y7POuMeD7nIR35wkJP85ChP+btNrvKWu/zl2mY5zGdO85rnW+A2z7nOdy5smfP850D/r7nP g070op986EZPutIvjvSlO/3pCW861KdOdX5LvepYz7q7r671rntd3Fz/utjHbu2wk/3saFe22dPO 9rYDe+1uj7vcbQ33udt97nW/u97Znve9+33sff+74LUe+MEbfuqFP7zilZ74xTs+6I1/vOR1HvnJ W37mlb+85lWe+c17fuSd/7zoOR760Zu+4qU/veodnvrVu77kOH+97IUe+9nb3uWtv73u65373ft+ 67X/vfA33vvhG3/cxT++8r2d/OU7/9rNf770pR396Vt/2dW/vvbhHfzte3/e2f+++BXe/fGbH93h P7/6aZ3+9btfAO1/v/rjL3/z07/+4r8/Zf69r//9a7///md9ABiA0jeABOh8BniAypeACmh8DNiA wveAEOh7EjiBuleBFmh7GJiBsreBHOh6HviBqheCImh6JFiConeCKOh5KriCmteCLmh5gcFqNFiD NniDOJiDOriDqZYAADs= ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0009_image009.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhFQAYAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAEAAgAS ABQAgQAAAAAAAP///wECAwI4hI8WkY0hxHIJxsioujc7y0kUGHpViI2o+K3mib4H2T2zWzF0/Ug7 C4uphMOSZicLdpKKhfPZKAAAOw== ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0009_image010.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhGQAkAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAEAAgAW ACEAgQAAAAAAAP8AAAECAwJahI8Yke22noRCsNlCrRcfvVkeFXIjWHYSWooT26rJsqS0B8tvPAKw i+OdhMFU76d7II9ETI5pHEYhtGqN+GtNs1rTp9tVcbWycdMHnn7T3hkb6A5ZI0prz1AAADs= ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0009_image011.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhGQAUAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAEAAgAX ABAAgQAAAAAAAP///wECAwI5hI9pwaGPmJgOKjlzXRdnHUXBR4LA6HglWaHjWjYLvDIRzW7HS8sP H9N1akKLx2aBSIrJhK9phBoKADs= ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0009_image012.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlh8gAzAXcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAADx ADIBgQAAAAAAAACAAP///wL/DI6py+0Po1xm2ouz3hyE2oXiCI7miaZKqbYt68byvNI2B9/6Hub8 j/ABh0SKsGg7Ipc/JdPlfEpn0ampas2ePlpq90vDgjHisdlSPkPS6naD7a7F5xouPQO/x/N7vR/9 N8EXaGZH6DB4CJZYqOgo95jAGJk12WVJKWUYiZn51DkF6rkkSjpKWVqUekq0SbjKOgTbFMvpOFvL 4+qHm7vTm+T7COwlfPtqfEv8kjz8t9wcxhvtfAdNLXN9hX1Mp80N5Q2uuNs4fviNc07ulr6u4n4R /741L2FPT6KGny/Cj9gP3T8GAwNuKAjJ4LMxCBXiWeTwFcKGEclcqohOC0WM//IqcURmZeNHQSFH gvxkMlA5WSlVamrp0hTMmKpmqnQn0mYEnDppAsnZ88HKYEGnsSxqlBbSpL+W8loG1CnAplKZSqtq NRvWrDGibiV4w+tXCkTHepsl1qykrgfSqg0yFMeHuW/nzAV1t267u3jj6r1EF57bv34P/j2MOLHi xYwbO34MObLkyZQrW76MObPmzZxnDvgMOrTo0aRLmz6NOnVnAKlbu34Nu/Tq2LRr2w49+7bu3ahz 8/4NfIDv4MRtDy+O/PXx5MxPL28OXfTz6NSnU4du/Trz7NqRc+9O/Dt44OLH8y5vXjf69MY7s8fu /v32+PK9r76PP7/+/fz7+///L1heAJ7B14D7BGbgIgYgmGAlJQyGX2ENkgLhfhJOqEqF+l2IoSwa 5sdghyF9GCGJ93HIWIh6oNhYAAIIwOKIq7n44osxUmiiMTTWaGNUN7bIY5A5/ejYjkHCyFCO0Rgp pIL9McnjREpiA2WNBakI4pFWOghglTbKOKCXSH4y5Tpe2kMkZmLGk2ZmZyKBZZdaftlKmf286aGI bc05pi52GrSmn3pKwicxbUZYaFh/RhRoEosymigVj0I6JyyH8tfoC5NilGkKl/rX6RWbjoQnCrvU h+p4l0QqagOpvnrdqlpaEhestjanEasdFHZrr8XlOqs/VfhK7G+V6IqHGMX/LnvbsZXKhQGz0sYW ErJosDFttq1V+ywZeWgLrmmhWLvGIOGeK50m5L7BCLruCvfJujO8i6663fJA77nx3otvvuDuGywQ /v7LRKk/DKxtwfLSgHC2Cgc8RMPTkrIwwxIzSzG/B1+8LJwVW8wxsR5rvHHIvqryMcgm34oyySWv bGsrKasM86syu/xyzanKMjPNOtfHM845/yyfDg8KPTTR7BnNRahFKL1zWD0inTTUqibBZ5RTWA00 1ln3+QTXRXud9T9ivyf115+acPbSZKttT9vppf01nUvIbR7dakuB99Vh1A32oEbXPWpiYtotuC5l Jx40xIwr7vjjvxy5tuRk/zRpeeOBZz454pxDXrhkLoYuOumif4566qqvznrrrr8Oe+yyz0577bbf jnvuuu/Oe+++/w58T3I7NnxjxTN2/GLJK7Z8Ys0j9vxh0f81vV7V13X9W9mrtb1Z3Y/1/VfhbzU+ VuVXdb5U6Tu1/lLtI/V+UfEHNb/wbRN/v/H5I7+/8v2HUjkz1M9TnyHdAEUVmtAd0B+jUeD/4ESa wi2QgaKR4AMh2MBYTJCCFWTFBnsQQQ9ekBQhHMUHOQiaSZ0QhBn0xApZmEATjrBgIQwgE14IwxQG YABlwuGuTNPDGX6ihI/w4Q9bWEQhUgiJSTzbF+bCREcYcVcFysQUt2FFJTFqT4vc46L3vAg+MIpP jOQjo/nMiD40qk+N7GOj+9wIPzjKT470o6P9nKg/PPLvbAUAADs= ------=_NextPart_01C7B3FE.615E8D00 Content-Location: file:///C:/6E4BB24E/Group_4_Wkshp_Presentation_files/slide0007.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"